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    Home / Central Data Catalog / HEALTH_AND_WELL-BEING / APHRC-URBZ-2015-1.0
Health_and_Well-Being

Epidemiology Ecology and Socio-Economics of disease Emergence in Nairobi- Urban Zoonosis Project

KENYA, 2013 - 2014
Health and Well-Being (HaW)
African Population and Health Research Center
Last modified July 10, 2015 Page views 550781 Documentation in PDF Metadata DDI/XML JSON
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Identification

IDNO
APHRC-URBZ-2015-1.0
Title
Epidemiology Ecology and Socio-Economics of disease Emergence in Nairobi- Urban Zoonosis Project
Country
Name Country code
KENYA KEN
Abstract
Background: It is often claimed that urbanization makes pathogen emergence more likely, but the underlying mechanisms are poorly understood. What characteristics of urban environments might predispose to an emergence event, and what is the contribution of livestock keeping to this process?

We focused on livestock as sources of these pathogens: emerging diseases are likely to be zoonotic in origin, and livestock pathogens, through the close interactions between livestock, their products and people, are at high of risk crossing the species barrier. We studied Escherichia coli (E. coli), an exemplar of many potential emerging pathogens, which exists in a diversity of hosts, in the environment, on food, in waste.

Objective: The overall objective of the project was to understand the mechanisms leading to the introduction of pathogens into urban populations, and their subsequent spread. More specifically, this study focused on the association between diarrhoea among children under the age of 5 years and E. coli in the faeces, E. coli flora in the immediate environment and in the food chain.

Approach: We conducted a case-control study in two Nairobi informal settlements, namely Korogocho and Viwandani, where the Nairobi Urban Health and Demographic Surveillance Survey (NUHDSS) is run. We selected children reporting diarrhoea within the last 3 days and matched them with similar controls who did not have diarrhoea. For both group, we collected data on socio-demographic characteristics of the household, livestock keeping and contact, residential history and a sample of stools. We also randomly sampled the environment; the usual garbage dumping site of the study participants' households, livestock if any, among others -- and from important sources of food like butcheries, milk shops etc in the vicinity.

Output and significance: Our approach, which builds on state-of-the-art methodologies across a range of disciplines, creates a benchmark for future studies, and is applicable to a wide range of situations where animals, people and the environment interact. The findings inform development of policy on urban livestock keeping by improving knowledge of the public health risks and by putting those risks in a wider socio-economic context, including the risks associated with alternative sources of livestock products.

Version

Version Date
2013-09-05
Version Notes
Version 1.0 (July 2015): Datasets edited and anonymised.

Scope

Keywords
Keyword Vocabulary
NUHDSS Nairobi Urban Health Demographic Surveillance Survey
KEMRI CMR Kenya Medica Research-Center for Microbiology Research
MCH Maternal and Child Health
IVP Indepth Vaccination Project
CCDC Case Control for Diarhoea among Children

Coverage

Geographic Coverage
Nairobi Informal settlement- Korogocho and Viwandani
Unit of Analysis
Individuals
Universe
This study was a population-based case-control design based on children in the Maternal and Child Health (MCH) study. Children =5yrs from the MCH sampling frame reporting diarrhoea within the last 3 days (case group) were matched with respect to sex and age with others (control group) who had not had diarrhoea in this period. For every “case”, two controls were drawn from the MCH, or from the wider NUHDSS if controls from the MCH were not available.

Producers and sponsors

Authoring entity/Primary investigators
Agency Name Affiliation
African Population and Health Research Center APHRC
Producers
Name Affiliation Role
Dr Catherine Kyobutungi Research Organization Principal Investigator
Dr Eric Fever Institute of Infection and Global Health, University of Liverpool Co - Principal Investigator
Funding Agency/Sponsor
Name Abbreviation Role
Medical Research Council MRC Funder

Sampling

Sampling Procedure
The study was based on the MCH sampling frame. This sampling included all children born within the NUHDSS between 2006 and 2010, and who had been previously recruited in the MCH study between the ages of 1 to 6 months. Those children had been followed up quarterly since their recruitment. Some of those children were ineligible for this study as they were older than 5, but those who met the age criteria were offered an opportunity to participate.

Questionnaires about the maternal and child health (ERB approval N0 KEMRI/RES/7/3/1/) were administered by fieldworkers to mothers or in case she was absent, to another close caregiver of the child. Diarrhoea which was explained to the respondents as >3 loose stools in 24 hours within the last three days was easily recognized by the mother or the caregiver. A child found to have diarrhoea was offered the opportunity to be included in the study.

Fieldworkers were given a list of children in the MCH study stratified by enumeration area, age and sex. Respondents (children =5yrs) from the MCH sampling frame reporting diarrhoea within the last 3 days were offered the opportunity to participate in the study. Each "case" was matched with respect to sex, age with two controls who had not had diarrhoea in this period. Those two controls were drawn from the same enumeration area and the MCH sample preferably or the wider NUHDSS if no control from the MCH was available. The nearest match was selected and if (s)he declines to participate then the second nearest matching control was selected and so on.
Deviations from the Sample Design
None
Weighting
Previous studies indicated that the point prevalence of diarrhoea in child cohorts in Kenya is ~18%-30% , or approximately 8 diarrhoea days per child per year , such that 750 to 1600 children with diarrhoea could be reasonably recruited from the MCH.

Conservatively assuming 20% decrease in the prevalence of diarrhoea and using a formula to get proportion of cases exposed, The number of cases required was 215. Thus as few as 215 “cases” could give us 90% power to detect significant associations at 5% significance level with odds ratios of at least 1.8 odds ratio

Data Collection

Dates of Data Collection (YYYY/MM/DD)
Start date End date
2013-09-05 2014-04-25
Mode of data collection
Face-to-face [f2f]
Supervision
The data collection consisted of four teams of 15 field workers, a supervisor for each team of either gender and a clinical officer for each site. Recruitment was done based on past performance and experiences in surveys, ability to relate to the target group, and ability to speak the survey languages.

The training of data collectors consisted a detailed, question-by-question explanation of the questionnaires/interview guides, demonstration of interviewing techniques through role-plays, group discussions, research ethics, procedures for seeking of informed consent, and field logistics. The supervisors received additional training on management of data collection; team dynamics, survey planning and logistics, observing interviews, and spot checking for data quality.
Type of Research Instrument
This study used the WHO definition of diarrhea as “the passage of 3 or more loose or liquid stools per day”. Pre-tested structured questionnaires to gather information on household economic data for a wealth ranking exercise, food consumption habits, food sources, livestock keeping (in the city or in rural homes), animal contact, hygiene habits, water sources, water treatment etc. Risk factor data e.g. residential history, food eating habits, livestock or animal contact etc. will be collected. In addition, clinical examination was performed by a clinical officer on the children =5yrs and measurements taken for weight, height, Mid-Upper Arm Circumference, temperature, as well as a recent history of a range of signs and symptoms (e.g. headache, splenomegaly, membrane palour, weight loss, diarrhoea, vomiting, chest pain, tiredness, known disease episodes, etc.).

Data access

Contact
Name Affiliation Email URI
African Population and Health Research Center APHRC datarequests@aphrc.org www.aphrc.org
Conditions
All non-APHRC staff seeking to use data generated at the Center must obtain written approval to use the data from the Director of Research. This form is developed to assess applications for data use and facilitate responsible sharing of data with external partners/collaborators/researchers. By entering into this agreement, the undersigned agrees to use these data only for the purpose for which they were obtained and to abide by the conditions outlined below:

1. Data Ownership: The data remain the property of APHRC; any unauthorized reproduction and sharing of the data is strictly prohibited. The user will, therefore, not release nor permit others to use or release the data to any other person without the written authorization from the Center.

2. Purpose: The provided data must be used for the purpose specified in the Data Request Form; any other use not specified in the form must receive additional or separate authorization.

3. Respondent Identifiers: The Center is committed to protecting the identity of the respondents who provide information in its research. All analytical data sets (both qualitative and quantitative) released by the Data Unit MUST are stripped of respondent identifiers to protect the identity of the respondents. By accepting to use APHRC data, the user is pledging that he/she will not, under any circumstance, regenerate the identifiers or permit others to use the data to learn the identity of any individual, household or community included in any data set.

4. Confidentiality pledge: The user will not use nor permit others to use the data to report any information in the data sets that could identify, directly or by inference, individuals or households.

5. Reporting of errors or inconsistencies: The user will promptly notify the Head of the Statistics and Survey Unit any errors discovered in the data as soon as the errors are discovered.

6. Publications resulting from APHRC data: The Center requires external collaborators to work with APHRC staff on all publications resulting from its data. In order to facilitate this, lead authors should send a detailed concept note of the paper (including the background, rationale, data, analytical methods, and preliminary findings) to the Principle Investigator (or Theme Leader) for the project (with a copy to the Director of Research), who will circulate the abstract to concerned researchers for possible expression of interest in participating in the publication as co-authors. Any exception to the involvement of APHRC staff should be approved by the Director of Research, APHRC.

7. Security: The user will take responsibility for the security of the data by ensuring that the data are used and stored in a secure environment where access is password protected. This will ensure that non-authorized people should not have access to the data.

8. Loss of privilege to use data: In the event that APHRC determines that the data user is in violation of the conditions for using the data, or if the user wishes to cancel this agreement, the user will destroy the data files provided to him/her. APHRC retains the right to revoke this agreement or informs publishers to withhold publication of any work based wholly or in part on its data if the conditions for using the data are violated.

9. Acknowledgement: Any work/reports from this data must acknowledge APHRC as the source of these data. For example, the suggested acknowledgement for NUHDSS data is:

"This research uses livelihoods data collected under the longitudinal Nairobi Urban Health and Demographic Surveillance System (NUHDSS) since 2006. The NUHDSS is carried out by the African Population and Health Research Center in two slums settlements (Korogocho and Viwandani) in Nairobi City."

Additionally all funders, the study communities that provided the data, and staff who collected and analyzed or processed the data should be acknowledged.

10. Deposit of Reports/Papers: The user should submit electronic and paper copies of all publications generated using APHRC data to the Policy Engagement and Communications Department, with copies to the Director of Research.

11. Change of contact details: The user will promptly inform the Director of Research of any change in your personal details as contained on this data request form.
Citation requirement
African Population and Health Research Center, Epidemiology Ecology and Soci-Economics of disease Emergence in Nairobi- Urban Zoonosis, Kenya, July 2015. APHRC, Nairobi - Kenya. doi:11239/176-2015-033-1.0

Disclaimer and copyrights

Disclaimer
The user of the data acknowledges that APHRC and the relevant funding agency bear no responsibility for use of the data or for interpretations or inferences based upon such uses.
Copyright
© APHRC, 2015

Metadata production

Document ID
APHRC-URBZ-2015-1.0
Producers
Name Abbreviation Affiliation Role
African Population and Health Research Center APHRC APHRC Meta data producer
Date of Production
2015-07-09
Document version
Version 1.0
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